Recent years saw the rise of vaginal infections in the category of obstetric-gynecological disorders and diseases. According to various authors, the statistics for vaginal infections vary from 30% to 60% and even 80% of all inflammatory diseases of the genital organs. Bacterial vaginosis is a risk factor that can cause severe pathology of female genital organs and lead to pregnancy and childbirth complications.
Several authors showed in their studies the link between the disease and chorioamnionitis, postpartum endometritis, premature birth and birth of low birth-weight babies, inflammatory processes of the genital organs, purulent septic complications in the mother and child in the postpartum period, and other obstetric and neonatal pathology. In this regard, early diagnosis and timely etiotropic therapy can help prevent the development of complications and improve the effectiveness of treatment.
Bacterial vaginosis disrupts vaginal microbiocenosis and encourages the growth of harmful endogenous microflora. In this case, the proper microflora of the vagina is replaced by other microorganisms like Bacteroides, Fusobacterium, Peptostreptococcus, Veillonellas, Gardnerella and Mycoplasma.
As a rule, patients with bacterial vaginosis complain of unusual smelly white or grey discharges from the genital tracts, especially after intercourse or during menstruation. Is untreated the unconformable symptoms can last for years. Within time, the discharge turns yellow-green, it also thickens and has an unpleasant smell. Sometimes it looks like sticky foam.
Most of the patients (63.9%) complain of bacterial vaginosis, which can develop as a complication of cervical ectopia, leukoplakia, endocervicitis and endometriosis. Vaginosis is also often concurrent with menstrual cycle disorders in women who have been using the intrauterine contraceptive device or coil longer than five years.
There are many ways to treat the disease. Doctors often prescribe Flagyl (Metronidazole) as a drug of choice for etiotropic therapy of vaginosis. They prefer Flagyl for its broad anti-anaerobic spectrum of action. While in a microbial cell, Metronidazole turns into an active form and binds DNA to blocks the nucleic acids synthesis. If bacterial vaginosis is diagnosed for the first time, a patient is recommended to take one 500 mg Flagyl tablet twice a day for a week.
The half-life of the drug is 8-10 hours: it is entirely removed from the body after 1-2 days after administration. Flagyl is removed via urine in unchanged form as metabolites. Flagyl can cause a loss of appetite, dryness and unpleasant taste in the mouth, nausea, vomiting, diarrhea, headache, rashes and itching. Side effects may go away after you stop taking medicine.